The retrosplenial cortex is important for both the acquisition and retrieval of context fear, as blocking NMDA receptors within the RSC disrupts the retrieval of both recent and remote context fear memory (Corcoran et al., 2011) and blocking protein synthesis in the RSC or silencing the RSC during training impairs the acquisition of contextual ...Nicole C. Ferrara 1,2, Janine L. Kwapis 3 and Sydney T rask 4,5 * ... Kwapis and Wood, 2014), suggesting plasticity in. Frontiers in Synaptic Neuroscience 02 frontiersin.org. fnsyn-15-1146665 Fe ...Undergraduate Research and Fellowships Mentoring Office. 321 Boucke Building. University Park, PA 16802. 814-863-8199 | [email protected] L. Kwapis, Y. Alaghband, +14 authors M. Wood. Biology, Psychology. Nature Communications. 2018; TLDR. It is shown that epigenetic regulation of clock gene ...The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneration-incompetent central spinal cord …Abstract. The circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian …Sydney Trask 1 , Nicole C Ferrara 2 , Aaron M Jasnow 3 , Janine L Kwapis 4 Affiliations 1 Department of Psychological Sciences, Purdue University, West Lafayette, IN, 47907, …Janine L. Kwapis (301 Qureshey Research Lab, University of California Center for the Neurobiology of Learning and Memory Irvine Center for Addiction Neuroscience (ICAN), University of California Institute for Memory Impairments and Neurological Disorders, University of California)Janine L. Kwapis et al. J. Neurosci. 2019;39:4999-5009 ©2019 by Society for Neuroscience Hippocampal overexpression of Nr4a1, Nr4a2, or both transcripts enhances OLM. A, Experimental design. Janine L. Kwapis et al. J. Neurosci. 2019;39:4999-5009 ©2019 by Society for Neuroscience Behavioral characterization of young, AU, and AI rats. ...Feb 1, 2023 · Janine L. Kwapis, Y. Alaghband, +14 authors M. Wood. Biology, Psychology. Nature Communications. 2018; TLDR. It is shown that epigenetic regulation of clock gene ... Feb 21, 2023 · Janine Kwapis, assistant professor of biology at Penn State, has been appointed as the first Paul Berg Early Career Professor in the Biological Sciences in recognition of her research contributions, teaching, and service to the Department of Biology and the Eberly College of Science. The professorship was created through an endowment ... The circadian clock plays a prominent role in neurons during development and throughout aging. This review covers topics pertinent to the role of 24-h rhythms in neuronal development and function, and their tendency to decline with aging. Pharmacological or behavioral modification that augment the function of our internal clock may be central to decline of cognitive disease and to future ...Chad W Smies 1 , Kasuni K Bodinayake 1 , Janine L Kwapis 2 Affiliations 1 Department of Biology, Pennsylvania State University, University Park, PA 16802, USA. 2 Department of Biology, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: [email protected]. PMID: 35697314 DOI: 10.1016/j.nlm.2022.107651 Abstract The …Janine Kwapis, assistant professor of biology at Penn State, has been appointed as the first Paul Berg Early Career Professor in the Biological Sciences in recognition of her research contributions, teaching, and service to the Department of Biology and the Eberly College of Science.Alberto J López 1 2 3 , Yousheng Jia 4 , André O White 5 , Janine L Kwapis 1 2 , Monica Espinoza 1 2 3 , Philip Hwang 1 2 3 , Rianne Campbell 1 2 3 , Yasaman Alaghband 1 2 3 , Om Chitnis 1 2 3 , Dina P Matheos 1 2 3 , Gary Lynch 4 , Marcelo A Wood 1 2 3Added Creator Janine L. Kwapis November 15, 2021 13:11 by Researcher Metadata Database. Published November 15, 2021 13:11 by Researcher Metadata Database. Updated February 28, 2022 22:44 ...Finally, Bellfy and Kwapis review the evidence that the reconsolidation process may allow existing memories to update in response to new, relevant information . In their review, the authors outline the major behavioral paradigms used to study reconsolidation and describe the different molecular mechanisms across the brain that …This research was supported by the National Institutes of Mental Health (NIMH) Grant R01MH069558 to Fred J. Helmstetter and NIMH Grant F31MH090685 to Janine L. Kwapis. Recommended articles References (103)Histone deacetylase 3 (HDAC3) is the most highly expressed Class I HDAC in the brain, and this specific HDAC is a powerful negative regulator of learning and memory processes (Kwapis et al., 2017; Malvaez et al., 2013; McQuown et al., 2011; Rogge et al., 2013).Janine Kwapis. Assistant Professor of Biology. 516 Mueller Lab University Park, PA She/Her; [email protected]; Bio & Links; Publications; Research Summary. Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments. Huck Graduate Students. Lauren Bellfy; Chad Brunswick; Hannah Boyd; …Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. Wood Europe PMC is an archive of life sciences journal literature. https://orcid.orgPeer-reviewed scientific journal publishing basic neuroscience research in the areas of neuronal plasticity, learning and memoryWe have previously shown that trace fear extinction requires the RSC (Kwapis et al., 2014) and have hypothesized that trace memory may be stored in a distributed cortical network that includes prelimbic and retrosplenial cortices (Kwapis et al., 2015). Whether the RSC participates in acquiring and storing cued trace fear, however, is currently ...Previous work from our lab (Kwapis et al., 2011, Kwapis et al., 2014, Kwapis et al., 2015) has demonstrated that a 6-trial trace fear conditioning protocol with a variable intertrial interval (ITI) of 240 ± 20 s produces approximately the same level of freezing as 4 trials of delay fear conditioning with a shorter ITI of 110 ± 20 s.Previous work from our lab (Kwapis et al., 2011, Kwapis et al., 2014, Kwapis et al., 2015) has demonstrated that a 6-trial trace fear conditioning protocol with a variable intertrial interval (ITI) of 240 ± 20 s produces approximately the same level of freezing as 4 trials of delay fear conditioning with a shorter ITI of 110 ± 20 s.The Neuroscience section of the Current Protocols journal covers research methods involving molecular pathways, synaptic transmission, behavioral techniques & imaging.The retrosplenial cortex (RSC) is known to play a role in the retrieval of context memory, but its involvement in memory formation and consolidation is unclear. To better characterize the role of the RSC, we tested its involvement in the formation and ... Graham D. L. et al.. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat. Neurosci. 10, 1029-1037 (2007). [Google Scholar] Graham D. L. et al.. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol. Psychiatry 65, 696-701 (2009).Lauren Bellfy and Janine L. Kwapis * Department of Biology , Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University , University Park, P A 16802, USA ...The abilities to encode, maintain, and recall memories are crucial cognitive processes that allow organisms to function in a changing world. Disruptions in memory processes have been linked to several neuropsychiatric disorders ranging from substance abuse disorders, anxiety, and trauma-related disorders, as well as normal cognitive decline associated with aging.Oct 11, 2019 · Fear of movement-related pain leads to two types of avoidance behavior: excessive avoidance and pain-inhibited movement. Excessive avoidance is an absence of movement by fear, and pain-inhibited movements involve a change in motor behavior for the purpose of protecting the painful part. Here, we sought to clarify the acquisition process and adaptation of fear for each avoidance behavior ... Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. WoodAug 20, 2018 · The work of Y.L., C.M., S.C., and P.B. was in part supported by NSF grant IIS- 1550705, DARPA grant D17AP00002, and NIH GM123558 to P.B. E.M. was supported by a long-term EMBO post-doctoral fellowship and an ARC Foundation award and work in the P.S.-C. lab was supported by grants from the National Institutes of Health, INSERM, and the Novo ... The editors depend heavily on outside reviewers in forming opinions about papers submitted to eNeuro and would like to formally thank the following individuals for their help during the past year. Wickliffe C. Abraham Rochelle Ackerley Kirsten C. S. Adam Omar J. Ahmed Turgay Akay Allyson Alexander Hossein Aleyasin Topaz Altman Krishna Chaitanya Aluri Rachel M. Anderson William David Andrews ...The Editors depend heavily on outside reviewers in forming opinions about papers submitted to JNeurosci and would like to formally thank the following individuals for their help during the past year.. Esther Aarts. Ishmail Abdus-Saboor. Ted Abel. Moshe AbelesFirst, we sought to compare learning-induced expression of Per1 between the young and aging RSC. Here, young (8-week-old) and aging (18-month-old) mice were either trained in OLM or left in their homecage at ZT5 and then sacrificed an hour later to examine Per1 expression via qPCR. Homecage control mice were handled and habituated to the context as part of the OLM protocol but remained in ...Janine L. Kwapis, Timothy J. Jarome, Nicole C. Ferrara, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 16 Scopus citations. Overview; Fingerprint; Abstract. Established memories undergo a period of vulnerability following retrieval, a process termed 'reconsolidation.' Recent work has shown ...Dec 13, 2019 · Kwapis JL, Alaghband Y, Kramar EA, Lopez AJ, Vogel Ciernia A, White AO, Shu G, Rhee D, Michael CM, Montellier E, Liu Y, Magnan CN, Chen S, Sassone-Corsi P, Baldi P, Matheos DP, Wood MA, 2018. Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory . This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.Janine Kwapis; Timothy J Jarome; Jonathan L. Lee; Fred J Helmstetter; The retrosplenial cortex (RSC) is known to play a role in the retrieval of context memory, but its involvement in memory ...Janine L. Kwapis [email protected] Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, Pennsylvania. Corresponding author: [email protected] Search for more papers by this author. Destiny S. Wright, Destiny S. Wright.7 Des 2016 ... Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala. Janine L Kwapis, ...Destiny S. Wright, 1 Kasuni K. Bodinayake, 1 and Janine L. Kwapis 1, * Destiny S. Wright 1 Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, PA, USAAccess the most recent version at doi:10.1101/lm.030510.113 Learn. Mem. 2013 20: 290-294 Marieke R. Gilmartin, Janine L. Kwapis and Fred J. Helmstetter contextual ...L-type VDCCs participate in behavioral-LTP and memory retention. Yuan-Yuan Han, Xiao-Dong Wang, Li Liu, Hong-Mei Guo, ... Chu-Hua Li. Pages 75-83 View PDF. Article preview. ... Yasaman Alaghband, Janine L. Kwapis, Alberto J. López, André O. White, ... Marcelo A. Wood. Pages 94-104 View PDF.Timothy J. Jarome, Craig T. Werner, # Janine L. Kwapis, # and Fred J. Helmstetter * Efthimios M. C. Skoulakis, Editor. Author information Article ... Mouledous L, Frances B, et al. Protein degradation, as with protein synthesis, is required not only during long-term spatial memory consolidation but also reconsolidation. Eur J Neurosci. ...Janine L. Kwapis; Yasaman Alaghband; Marcelo A. Wood; Article 15 Jun 2019. Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.Kwapis, Janine L Alaghband, Yasaman Keiser, Ashley A et al. Publication Date 2020 DOI 10.1038/s41386-019-0438- Peer reviewed eScholarship.org Powered by the California Digital Library University of California. ARTICLE Aging mice show impaired memory updating in the novel OUL updating paradigmAbstract. The circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian …Janine L. Kwapis, Ph.D., Department of Biology, Penn State University Public Neuroscience Seminar; Wednesday, December 4th, 2019; 11:00 am – 12:00pm; Fralin Auditorium; Aging is accompanied by impairments in both long-term memory and circadian rhythmicity.Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp and ...Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (41,238,717 articles, preprints and more) (41,238,717 articles, preprints and more)Bellfy L, Kwapis JL. (2020) Molecular Mechanisms of Reconsolidation-Dependent Memory Updating. International Journal of Molecular Sciences. 21: Wright DS, Bodinayake KK, Kwapis JL. (2020) Investigating Memory Updating in Mice Using the Objects in Updated Locations Task. Current Protocols in Neuroscience. 91: e87: Navabpour S, Kwapis JL, Jarome TJ.Janine Kwapis is a professor in the Biological Sciences department at Penn State University - see what their students are saying about them or leave a ...AU - Kwapis, Janine L. AU - Helmstetter, Fred J. PY - 2014/6. Y1 - 2014/6. N2 - Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory. PKMζ, an autonomously active isoform of PKC, is hypothesized to sustain those changes that occurred during ...The beneficial effect of prior experience on the acquisition of spatial memory in rats with CA1, but not large hippocampal lesions: a possible role for schema formationNicole C. Ferrara1,2, Janine L. Kwapis3 and Sydney Trask4,5* 1Discipline of Physiology and Biophysics, Rosalind Franklin University, North Chicago, ... Kwapis and Wood,2014), suggesting plasticity in Frontiers inSynaptic Neuroscience02frontiersin.org. fnsyn-15-1146665 February 24, 2023 Time: 15:4 # 3Janine L. Kwapis, 1 Yasaman Alaghband, 1 Alberto J. López, 1 Jeffrey M. Long, 2 Xiang Li, 1 Guanhua Shu, 1 Kasuni K. Bodinayake, 1 Dina P. Matheos, 1 Peter R. Rapp, 2 and ... AG051807, and AG050787 to M.A.W., the National Institute on Aging Grants F32 AG052303 and K99 AG056596 to J.L.K., and in part by the Intramural Research Program of the ...Janine L Kwapis; Timothy J Jarome; The past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to ...Europe PMC is an archive of life sciences journal literature.Finally, Bellfy and Kwapis review the evidence that the reconsolidation process may allow existing memories to update in response to new, relevant information . In their review, the authors outline the major behavioral paradigms used to study reconsolidation and describe the different molecular mechanisms across the brain that support this ...Timothy J Jarome 1 , Nicole C Ferrara 1 , Janine L Kwapis 1 , Fred J Helmstetter 2 Affiliations 1 Department of Psychology, University of Wisconsin-Milwaukee, United States. 2 Department of Psychology, University of Wisconsin-Milwaukee, United States. Electronic address: [email protected]. ...Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association.Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 64 Scopus citations. ... of two cues separated by an empty period of time. We have previously shown that trace fear extinction requires the RSC (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter ...Sydney Trask 1 , Nicole C Ferrara 2 , Aaron M Jasnow 3 , Janine L Kwapis 4 Affiliations 1 Department of Psychological Sciences, Purdue University, West Lafayette, IN, 47907, United States. The rhesus macaque is a long-lived nonhuman primate (NHP) with a brain structure similar to humans, which may represent a valuable translational animal model in which to study human brain aging. Previous magnetic resonance imaging (MRI) studies of age in rhesus macaque brains have been prone to low statistical power, unbalanced sex ratio and ...AU - Kwapis, Janine L. N1 - Funding Information: This work was supported by the National Institutes of Health (grants R00AG056596 and R21AG068444) awarded to J.L.K.; the Whitehall Foundation (grant 2020-05-06 to J.L.K.); and was conducted while Janine Kwapis was a Glenn Foundation for Medical Research and AFAR Grant for Junior Faculty awardee ...The retrosplenial cortex (RSC) is known to play a role in the retrieval of context memory, but its involvement in memory formation and consolidation is unclear. To better characterize the role of the RSC, we tested its involvement in the formation and ...Janine L. Kwapis, Ph.D. (she/her) principal investigator; The Paul Berg Early Career Professor in the Biological Sciences. Janine received her Ph.D. in Behavioral Neuroscience from the University of Wisconsin-Milwaukee in 2013 where she studied the circuit-level mechanisms underlying trace and delay fear conditioning under Dr. Fred Helmstetter.She then trained as a postdoc under Dr. Marcelo ...21 Feb 2023 ... Janine Kwapis. Assistant Professor of Biology. Janine Kwapis. 516 Mueller Lab University Park, PA; She/Her; jlk855 ...Feb 21, 2023 · Janine Kwapis, assistant professor of biology at Penn State, has been appointed as the first Paul Berg Early Career Professor in the Biological Sciences in recognition of her research contributions, teaching, and service to the Department of Biology and the Eberly College of Science. The professorship was created through an endowment ... Janine L. Kwapis; Alberto J. López; André O. White; Osasumwen V. Aimiuwu; Amni Al-Kachak; Kasuni K. Bodinayake; Nicole C. Oparaugo; Richard Dang; Mariam Astarabadi; Dina P. Matheos; Marcelo A. Wood; Neurobiology of Learning and Memory. Published on 01 Nov 2017. 0 views XX downloads; XX citations; Context and Auditory Fear are …Thus, Per1 may independently function within the DH to regulate memory in addition to its known role in regulating the circadian system within the SCN. Per1 may therefore exert local diurnal control over memory consolidation within the DH. The circadian system influences many different biological processes, including memory performance. Histone deacetylase 3 (HDAC3) is the most highly expressed Class I HDAC in the brain, and this specific HDAC is a powerful negative regulator of learning and memory processes (Kwapis et al., 2017; Malvaez et al., 2013; McQuown et al., 2011; Rogge et al., 2013).Janine L Kwapis 1 , Timothy J Jarome 1 , Fred J Helmstetter 2 Affiliations 1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA. 2 Department of Psychology, University of PMID: 25512576 PMCID: 10. ...Janine Kwapis Assistant Professor, Biology h-index 1482 Citations 24 h-index 2009 2023 Research activity per year Overview Fingerprint Network Grants & Projects (4) Research output (43) Similar Profiles (1) If you made any changes in Pure these will be visible here soon. Personal profileAndré O. White, Enikö A. Kramár, Alberto J. López, Janine L. Kwapis, John Doan, David Saldana, M. Felicia Davatolhagh, Yasaman Alaghband, Mathew Blurton-Jones ...AU - Kwapis, Janine L. AU - Helmstetter, Fred J. PY - 2014/6 Y1 - 2014/6 N2 - Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory.Kwapis, Janine Lynn: F31 Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). The Role of Protein Kinase Mzeta in Hippocampal-Dependent Memory Maintenance.Chad W. Smies a, Janine L. Kwapis a, ∗ a Department of Biology, Pennsylvania State University, University Park, PA b Department ofNeurobiology and Behavior, University California, Irvine, CA a r t i c l e i n f o Article Aginghistory: both Received 17 October 2022 Revised 3 February 2023 Accepted 18 February 2023 Available online 23 February ...Europe PMC is an archive of life sciences journal literature.1. To whom all correspondence should be addressed: Janine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]. Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory ConsolidationAU - Kwapis, Janine L. AU - Helmstetter, Fred J. N1 - Funding Information: This research was supported by the National Institute of Mental Health (NIMH) Grants R01MH069558 and R03MH090426 to Fred J. Helmstetter and NIMH Grant F32MH083422 to Marieke R. Gilmartin. We would like to thank Mary Lonergan for assistance with the drug microinjections.Janine L Kwapis Memory is not a stable record of experience, but instead is an ongoing process that allows existing memories to be modified with new information through a reconsolidation-dependent ...Janine l. kwapis
The past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to precisely manipulate the genome and epigenome in behaving animals.Hervera A, Zhou L, Palmisano I, et al. (2019) PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure. The Embo Journal Kwapis JL, Alaghband Y, López AJ, et al. ( 2019 ) HDAC3-mediated repression of the family contributes to age-related impairments in long-term memory.Janine L. Kwapis. Department of Neurobiology and Behavior, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. UC Irvine Center for Addiction Neuroscience, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. Search for more papers by this author.L-type VDCCs participate in behavioral-LTP and memory retention. Yuan-Yuan Han, Xiao-Dong Wang, Li Liu, Hong-Mei Guo, ... Chu-Hua Li. Pages 75-83 View PDF. Article preview. ... Yasaman Alaghband, Janine L. Kwapis, Alberto J. López, André O. White, ... Marcelo A. Wood. Pages 94-104 View PDF.Jan 19, 2023 · The circadian clock plays a prominent role in neurons during development and throughout aging. This review covers topics pertinent to the role of 24-h rhythms in neuronal development and function, and their tendency to decline with aging. Pharmacological or behavioral modification that augment the function of our internal clock may be central to decline of cognitive disease and to future ... Sydney Trask 1 , Nicole C Ferrara 2 , Aaron M Jasnow 3 , Janine L Kwapis 4 Affiliations 1 Department of Psychological Sciences, Purdue University, West Lafayette, IN, 47907, United States. 2 Department of Pharmacology, Rosalind Franklin University of ...Stored memories enter a temporary state of vulnerability following retrieval known as 'reconsolidation', a process that can allow memories to be modified to incorporate new information.Timothy J Jarome 1 , Janine L Kwapis, Steven H Nye, Fred J Helmstetter. Affiliation 1 Department of Psychology, University of Wisconsin, 2441 East Hartford Ave, Milwaukee, WI 53201, USA. PMID: 19757016 PMCID: PMC5275762 DOI: 10.1007/s10519-009 ...Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. WoodThe retrosplenial cortex (RSC) is known to play a role in the retrieval of context memory, but its involvement in memory formation and consolidation is unclear. To better characterize the role of the RSC, we tested its involvement in the formation and ...Chad W Smies, Kasuni K Bodinayake, Janine L Kwapis. Published in. Neurobiology of learning and memory. Pages 107651. Jun 10, 2022. Epub Jun 10, 2022. Abstract The circadian system plays an important role in aligning biological processes with the external time of day.We investigated how sex modulates metabolic connectivity alterations in probable dementia with Lewy bodies (pDLB). We included 131 pDLB patients (males/females: 58/73) and similarly aged healthy controls (HC) (male/female: 59/75) with available (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans.AU - Kwapis, Janine L. N1 - Funding Information: Funding: This research was funded by NIH grants K99/R00AG056586 (J.L.K.) and R21AG068444 (J.L.K.), Whitehall Foundation Grant #2020-05-06 (J.L.K.), startup funds from the Eberly College of Science and Department of Biology at Pennsylvania State University (J.L.K.) and the National Institute on ...Lauren Bellfy and Janine L. Kwapis * Department of Biology , Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University , University Park, P A 16802, USA ...Janine L. Kwapis (301 Qureshey Research Lab, University of California Center for the Neurobiology of Learning and Memory Irvine Center for Addiction Neuroscience (ICAN), University of California Institute for Memory Impairments and Neurological Disorders ...Janine Kwapis; Timothy J Jarome; Jonathan L. Lee; Fred J Helmstetter; The retrosplenial cortex (RSC) is known to play a role in the retrieval of context memory, but its involvement in memory ...Janine L. Kwapis, PhD THE PAUL BERG EARLY CAREER PROFESSOR IN THE BIOLOGICAL SCIENCES; Assistant Professor of BiologyFeb 17, 2023 · Nicole C. Ferrara 1,2 Janine L. Kwapis 3 Sydney Trask 4,5* 1 Discipline of Physiology and Biophysics, Rosalind Franklin University, North Chicago, IL, United States 2 Center for Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University, North Chicago, IL, United States For delay conditioning, the UCS was delivered at the offset of the CS and the ITI was 110 ± 20 sec (total session duration, 17 min). Six-trial trace conditioning and four-trial delay conditioning produce similar levels of conditional fear to the CS (Kwapis et al. 2011). During training, rats learned to associate both the auditory CS and the ...Lauren Bellfy Janine L. Kwapis. Biology. International Journal of Molecular Sciences. ... The results indicate that spatial memory reconsolidation depends on the functionality of L-VDCC in dorsal CA1, that maintenance of subsequent reconsolidated memory trace depends on CaMKII, and suggest that the role played by both L-vdCC and …Previous work from our lab (Kwapis et al., 2011, Kwapis et al., 2014, Kwapis et al., 2015) has demonstrated that a 6-trial trace fear conditioning protocol with a variable intertrial interval (ITI) of 240 ± 20 s produces approximately the same level of freezing as 4 trials of delay fear conditioning with a shorter ITI of 110 ± 20 s.Jun 1, 2023 · Additionally, the RSC has been demonstrated to play an important role in both the retrieval (Corcoran et al., 2011) and formation (Kwapis et al., 2015; Urban et al., 2021) of contextual fear memory. Both the anterior RSC (aRSC) and the posterior RSC (pRSC) have been implicated in spatial memory, although these subregions may each support ... Histone deacetylase 3 (HDAC3) is the most highly expressed Class I HDAC in the brain, and this specific HDAC is a powerful negative regulator of learning and memory processes (Kwapis et al., 2017; Malvaez et al., 2013; McQuown et al., 2011; Rogge et al., 2013).The circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle, including memory processes, yet little is understood about how the clock interfaces with memory at a molecular level. The molecular circadian clock consists of four ... Janine L. Kwapis , Contributed equally to this work with: Craig T. Werner, Janine L. Kwapis Affiliation Department of Psychology, University of Wisconsin, Milwaukee, Wisconsin, United States of America ⨯ . Fred J. Helmstetter * E-mail: [email protected] L. Kwapis, Timothy J. Jarome, Janet C. Schiff, and Fred J. Helmstetter1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA Memory for delay fear conditioning requires the synthesis of new mRNA and protein in the basolateral amygdala. It isJanine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. WoodChristopher W Butler · Ashley A Keiser · Janine L Kwapis · Nicole C Berchtold · Vanessa L Wall · Marcelo A Wood · Carl W Cotman: Inhibitory learning of phototaxis by honeybees in a passive-avoidance task. Paul Marchal · Maria Eugenia Villar · Haiyang Geng · Patrick Arrufat · Maud Combe · Haydée Viola · Isabelle Massou · Martin Giurfa:The past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to precisely manipulate the genome and epigenome in behaving animals. Janine Kwapis, Janine Karbowski, Janinel Karbowski. Related to: Lindsey Nurenberg, 34 Betty R Masden, 72 Katherine M Nurenberg, 32 Nurenberg Lindsey, 34. Connected to: Glenn G Kwapis, 56 Ronald L Kwapis Elaine L Kwarcinski, 51 Bongsin H Kwark, 63 June Kwark, 57 Robert W Kwarren, 59 Joann N Kwarta, 51 Kenneth Kwarteng, 51 Nicholas Kwarteng, 32 ...Janine L. Kwapis, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Review article › peer-review. 43 Scopus citations. Overview; Fingerprint; Abstract. Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory. PKMζ, an ...Alaghband Y, Kwapis JL, López AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparaugo NC, Dang R, Astarabadi M, Matheos DP, Wood MA (2017) Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.Author links open overlay panel Timothy J. Jarome 1, Nicole C. Ferrara 1, Janine L. Kwapis, Fred J. Helmstetter. Show more. Add to Mendeley. Share. ... of memory and blocks the effect of protein synthesis inhibitor anisomycin on memory reconsolidation (Jarome, Ferrara, Kwapis, & Helmstetter, 2016; Jarome et al., 2011; Lee et al., 2008a). The ...Janine L Kwapis, Tim J Jarome, Nicole C Ferrara, & Fred J Helmstetter Context memory formation requires activity-dependent protein degradation in the hippocampus. Patrick K Cullen, Nicole C Ferrara, Shane E Pullins, & Fred J Helmstetter Input from the ...The retrosplenial cortex is important for both the acquisition and retrieval of context fear, as blocking NMDA receptors within the RSC disrupts the retrieval of both recent and remote context fear memory (Corcoran et al., 2011) and blocking protein synthesis in the RSC or silencing the RSC during training impairs the acquisition of contextual fear …Hannah M. Boyd1, Megan J. von Abo1, Istvan Albert2,3, Janine L. Kwapis1,* 1 Department of Biology, Pennsylvania State University, University Park, PA 16802, USA 2 Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA 3 Department of Biochemistry and Molecular Biology,International Journal of Molecular Sciences Editorial Special Issue "Molecular Mechanisms of Memory Formation and Modification" Timothy J. Jarome 1,2,* and Janine L. Kwapis 3,4,* Citation: Jarome, T.J.; Kwapis, J.L. Special Issue "Molecular MechanismsTimothy J. Jarome, Craig T. Werner, Janine L. Kwapis, Fred J. Helmstetter. Research output: Contribution to journal › Article › peer-review. 141 Scopus citations. Overview; Fingerprint; Fingerprint Dive into the research topics of 'Activity dependent protein degradation is critical for the formation and stability of fear memory in the ...Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during complex neural processes like memory consolidation. Individually, the molecular components and action of each of these sys …Jun 14, 2015 · We have previously shown that trace fear extinction requires the RSC (Kwapis et al., 2014) and have hypothesized that trace memory may be stored in a distributed cortical network that includes prelimbic and retrosplenial cortices (Kwapis et al., 2015). Whether the RSC participates in acquiring and storing cued trace fear, however, is currently ... Finally, Bellfy and Kwapis review the evidence that the reconsolidation process may allow existing memories to update in response to new, relevant information . In their review, the authors outline the major behavioral paradigms used to study reconsolidation and describe the different molecular mechanisms across the brain that …Kwapis, Janine L López, Alberto J et al. Publication Date 2017-11-01 DOI 10.1016/j.nlm.2017.09.001 Peer reviewed eScholarship.org Powered by the California Digital Library University of California. Distinct roles for the deacetylase domain of HDAC3 in the1. Introduction. Understanding the neural mechanisms that support long-term memory formation and storage is a fundamental goal of neuroscience. Historically, a large majority of this research has focused on identifying the molecular components of long-term memory formation and, accordingly, a broad understanding of the memory acquisition process has gradually emerged.Janine L. Kwapis, Timothy J. Jarome, and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively wellThis work was supported by grants from the US National Institutes of Health (DA025922, DA036984 and MH101491 to M.A.W.), the National Institute of General Medical Sciences of the National Institutes of Health (GM055246 supporting A.O.W. and A.J.L.), the Department of Education GAANN (P200A120165 supporting A.O.W. and A.J.L.), the US …NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioningMatthew celebrated 40th birthday on June 1. Matthew now resides at 965 Grace Str, State College, PA 16801. We know that Janine L Kwapis, Jackson A Thompson, and three other persons also lived at this address, perhaps within a different time frame. The number currently linked to Matthew is (414) 305-0269 (Cellco Partnership)Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp, Marcelo A. WoodBrain derived neurotropic factor (BDNF) supports neuronal survival, growth, and differentiation and is involved in forms of hippocampus-dependent and independent learning, as well as hippocampus-dependent learning. Extinction learning comprises active inhibition of no-longer relevant learned information, in conjunction with a decreased response of a previously learned behavior. It is highly ...Collectively, this review will serve as a guide to assist neuroscientists in identifying and choosing the appropriate genetic tools available to study the complex relationship between the brain and behavior. Keywords: Transgenic mice, knockouts, Cre, DREADDs, CRISPR, brain, behavior. The development of transgenic mice dates back to the early ...Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp, Marcelo A. WoodWe have previously shown that trace fear extinction requires the RSC (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter, 2014) and have hypothesized that trace …Jarome TJ, Kwapis JL, Werner CT, Parsons RG, Gafford GM, Helmstetter FJ (2012). The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation. Learn Mem 19: 300–306. [PMC free article] [Google Scholar] Jarome TJ, Werner CT, Kwapis JL, Helmstetter FJ (2011).DOI: 10.1016/j.neubiorev.2019.12.013 Corpus ID: 209352174; A neuroscientist's guide to transgenic mice and other genetic tools @article{Navabpour2019ANG, title={A neuroscientist's guide to transgenic mice and other genetic tools}, author={Shaghayegh Navabpour and Janine L. Kwapis and Timothy J Jarome}, journal={Neuroscience \& Biobehavioral Reviews}, year={2019}, volume={108}, pages={732 ...Results suggest that circadian activities of the MNK‐eIF4E axis contribute to the diurnal rhythms of some cognitive functions, highlighting a role for rhythmic translational control in circadian regulation of cognitive performance. Although it is well recognized that the circadian timing system profoundly influences cognitive performance, the underlying molecular mechanisms remain poorly ...Previous work from our lab (Kwapis et al., 2011, Kwapis et al., 2014, Kwapis et al., 2015) has demonstrated that a 6-trial trace fear conditioning protocol with a variable intertrial interval (ITI) of 240 ± 20 s produces approximately the same level of freezing as 4 trials of delay fear conditioning with a shorter ITI of 110 ± 20 s.Europe PMC is an archive of life sciences journal literature.The past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to precisely manipulate the genome and epigenome in behaving animals. Collectively, this review will serve as a guide to assist neuroscientists in identifying and choosing the appropriate genetic tools available to study the complex relationship between the brain and behavior. Keywords: Transgenic mice, knockouts, Cre, DREADDs, CRISPR, brain, behavior. The development of transgenic mice dates back to the early ...Author links open overlay panel Shaghayegh Navabpour a, Janine L. Kwapis b c, Timothy J. Jarome a d e. Show more. Add to Mendeley. ... Kwapis et al., 2018; Malleret et al., 2001; Vogel-Ciernia et al., 2013; White et al., 2016). Additionally, knock-in approaches can be used to create constitutively active forms of a protein ...Search life-sciences literature (42,985,652 articles, preprints and more) SearchThis work was supported by NIMH and NIDA grants (MH81004, MH101491, DA025922, DA036984, DA031989) to M.A. Wood and NIA T32 grant AG000096-31 to J.L.K. Go to: GlossaryEpigenetic mechanisms, which control gene expression to produce long-lasting changes in cellular function, may support the formation of fear memory underlying PTSD. We address here the role of epigenetic mechanisms in the formation, storage, updating, and extinction of fear memories. We also discuss methods of targeting these epigenetic ... Janine L Kwapis; Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during ...Chad W Smies, Kasuni K Bodinayake, Janine L Kwapis. Published in. Neurobiology of learning and memory. Pages 107651. Jun 10, 2022. Epub Jun 10, 2022. Abstract The circadian system plays an important role in aligning biological processes with the external time of day.Marieke R. Gilmartin,1 Janine L. Kwapis, and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA ... (Kwapis et al. 2011). During training, rats learned to associate both the auditory CS and the training context withJanine Kwapis, Thesis Supervisor Stephen Wade Schaeffer, Honors Advisor. 2. Sex-specific effect of the circadian clock gene Per1 in the retrosplenial cortex for context fear memory formation. Restricted (Penn State Only) Author: Lo, Chenyu Title:Normal aging is accompanied by cognitive impairments, most notably disruptions in memory formation and updating, the ability to incorporate new information into existing memory. As lifespans increase...Research Articles, Behavioral/Cognitive Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp and Marcelo A. Open in Who Shared Wrong byline? This byline is for a different person with the same name. ...We investigated how sex modulates metabolic connectivity alterations in probable dementia with Lewy bodies (pDLB). We included 131 pDLB patients (males/females: 58/73) and similarly aged healthy controls (HC) (male/female: 59/75) with available (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans.Sydney Trask, Nicole C. Ferrara, Aaron M. Jasnow, Janine L. Kwapis. November 2021 Pages 178-184 View PDF. Article preview. select article Environmental certainty influences the neural systems regulating responses to threat and stress. ... Jodi L. Pawluski, Elseline Hoekzema, Benedetta Leuner, Joseph S. Lonstein. February 2022 Article 104475 ...AU - Kwapis, Janine L. AU - Helmstetter, Fred J. PY - 2014/6. Y1 - 2014/6. N2 - Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory.Europe PMC is an archive of life sciences journal literature.Janine L. Kwapis, PhD THE PAUL BERG EARLY CAREER PROFESSOR IN THE BIOLOGICAL SCIENCES; Assistant Professor of Biology. [email protected]. My research focuses on ... . Ap physics 2 2021 frq scoring guidelines