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Because S369X had no dominant-negative effect on WT in electrophysiological experiments, we then examined the interaction between WT and S369X . Cotransfection with non-GFP-tagged WT exhibited a ... When this happens, it's usually because the owner only shared it with a small group of people, changed who can see it or it's been deleted.When this happens, it's usually because the owner only shared it with a small group of people, changed who can see it or it's been deleted.This Page Isn't Available Right Now. This may be because of a technical error that we're working to get fixed. Reload PageThe recently described S369X mutation causes a loss of the endoplasmic reticulum export motif and impaired trafficking of the channel to the plasma membrane . KCNJ18 was identified in 2010 in a search for genes associated with thyrotoxic periodic paralysis [29••]. 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